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How to live longer

January 6, 2018 Ben Yeoh
From Laura Deming (site)

From Laura Deming (site)

I don’t want to live to 100. Perhaps, I will change my mind as I grow older. I’m mostly unafraid of dying. I fear for those I leave behind. I partly attribute this to confronting the death of my father, and of my best friend while still studying. This is useful as I likely eat too much to be able to live to 100.

 

However, anti-ageing an interesting line of research and Laura Deming (who runs a VC fund looking at longevity) has a summary of the major lines of research.

 

I also find the studies of these old Okinawans intriguing (perhaps they are calorie restricted;,  The Okinawans have traditionally kept eating a low-calorie, low glycemic load diet, practicing calorie control in a cultural habit known as hara hachi bu - only eating until they are 80% full). Although it seems the >100 years old population in Japan has peaked.   

There is another pocket of super old in Sardinia, Italy.  The Sardinian pocket is known for male 100+.  (And a researcher postulates that laughter and walking help the Sardinian men ""Sardinian men are famous for gathering in the streets for a laugh every afternoon, something proven to relieve stress - the term "sardonic" originates in Sardinia.") A photo story on Sardinia.

Scroll below for a Ted talk on ageing, below are the sub-headings from Deming's work. 

From Deming:    Major areas of ageing research

  • Caloric Restriction   (eat less)

  • Insulin/IGF  (Insulin pathway, use anti-diabetic drugs)

  • Parabiosis (replacement using young blood)

  • Senescence  (removal of old cells)

  • Autophagy  (remove old cell parts better)

  • Hypothalamus  (growth hormone and hormone pathways)

  • Reproductive System (removal of gonads, cf Korean Eunuchs)

  • Mitochondria  (mutations in mitochondria)

  • Sirtuins  (alters DNA)


Link to Ted talk here.   And transcript here

In Sustainability, Science, Living Tags Ageing, Living
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