UK Healthcare spend as % GDP since 1970 vs Germany, OECD

I’ve been somewhat dissatisfied with the way UK healthcare has been examined over the long term. There are relatively few reports* so I thought I would slowly do my own assessment. Unsurprisingly, it’s taking a long time fitting this in my night hours. But, I have a couple of conclusions worth sharing already. I will try and drip these out over the year. The first conclusion is compared to France and Germany (and most of UK’s G7 peers where we have OK data). The UK has extremely significantly underspend on healthcare. 

The overall summary is that the UK underspent on healthcare for the 50 year period of 1970 to 2020. The underspend vs Germany and France s between 2 to 4 percent points of GDP.

But what does this mean in dollar or pound terms?

The approx. gap in USD is 46,000 per person less spend cumulatively per person or in absolute terms this is GBP989,719m (based on UK ONS GDP figures). So in the order of GBP1,000bn or GBP1 trillion. Another guide is that 2pp of GDP over 50 years is about 1 year’s worth of GDP! (Only ball park due to inflation etc.)

To give you scale of this underspend vs Germany. If all this money was spent on hospitals, given an average hospital is about GBP500m, then this would have been >1900 more hospitals. Today the UK has 1200 – 1300 hospitals (900 in England).

So we would have over double the number of hospitals if this had been spent on capital!


Here is a chart of this, and you can play around with the other OECD data (above).

One point of knowing this is that there is no quick fix to this. The UK has recentlyclosed the gap with France and Germany, but after 50 years of below average spending, one can not expect the gap to close.

Now there may be lessons from Japan, US etc - as US has significant above average spending. But the first topline macro point is that GBP1 trillion underspend relative to Germany means UK can not easily simply catch up in a few years.

What should UK innovation, ARIA, look at

Weird manifesto for UK ARPA or ARIA

My ideas:

-Progress Studies (including social progress and creativity)

-Basic Climate research

-How creativity happens

-Productivity schedules (sleep, diet, schedules)

-Educational Mastery

-Building Speed (how to do big projects fast[er])

-Healthcare speed, innovation, public health challenge trials,


The UK is creating a £800m sciency agency based on the US ARPA* an innovation agency. The UK agency will be called ARIA, Advanced Research and Invention Agency. This idea had considerable backing from former special adviser Dominic Cummings (see his lengthy blogs on this, links end*). While it has received criticism and isn’t a novel idea in innovation circles, we have it. So let’s make the most of it.


What is ARPA?

In brief at ARPA, around 100 program managers (PMs) with ~5 year appointments create and run programs to pursue high-level visions, for instance - what would make electric planes or hydrogen heating systems.


There is much written on what makes US DARPA work with a decent focus on having brilliant PMs. Also the similarities and differences on how IARPA (intelligence focused) and ARPA-E (energy focused) have also worked. So, I won’t dwell on that. 


UK’s ARIA is likely to be given the freedom to choose what it works on. Let’s put aside the debates on ARIA and the long history of innovation policy experts here and posit what we think ARIA should work on.

I’d like to float some weird and not so weird ideas I think a UK ARIA should focus on. I have a touch of weirdness about me so that fully qualifies me (tongue in cheek).

These ideas support areas which would have large public goods benefits (and some private sector benefits) but for various incentive/time horizon problems are not well suited to private actors.

I have 3 large buckets but with some off sub-buckets.

  •  Basic Climate research

  •  Progress Studies (after Cowen & Collinson)

  •  Healthcare (life extension and quality of life extension)


Basic Climate research: Trees and Seas 

While this falls under “net zero” area, my idea under basic climate research is more foundational than eg tackling hydrogen based systems for making carbon neutral steel.


There are several areas here, where - it seems to me - we simply do not understand the state of the world and its system but we might now have the technology and research to do this.

For instance, what is the true state of our forests, jungles and trees over the globe? Data and the interpretation of that data is unclear. Where are trees disappearing, where are we planting and how is it going?


Bill Gates is dismissive of trees as a climate solution*. The UN FAO has data, visualised by World in Data*, but other attempts to assess trees are contradictory.

This is due to problems of classifying types of trees (shrubs, types of trees etc.) and the aerial data needed. And there are problems with losing old trees (especially primary rain forest) and replacement of new trees.


I am far away from the literature and no expert but I sense a programme here and maybe one specific to UK and UK peat lands, tree afforestation etc. would be very useful in basic research.  Essentially, the same argument for seas and oceans and their contribution to carbon sinks.

Basic climate research is not super weird. But I think there are big basic knowledge gaps here which could be very valuable and items like trees are not best suited to private actors.

Progress Studies

  • How innovation happens, how to make it better. Same for social and ethical progress. Also,

  • Creativity, flow, educational mastery


This is weirder although Tyler Cowen, Patrick Collinson et al is making it a lot less weird.


This would need to go beyond “Cities and innovation clusters show agglomeration affects” (known and somewhat trite, IMO, in that difficult for policy to seeming build upon) but can we drive real insights here? Small teams? Big teams? Collaboration from cross-disciplines which are neither too far, nor too close. The impacts from regulation (are the de-regulation cries correct in all respects? ). 

There will be a tendency to look at this in the hard sciences and the inventions, innovations etc. there (and there is a literature here). And I think understanding that will be useful especially eg in medical science, software and the like, but my weird question is what about social progress?

There is consensus today that slavery is bad. I think that counts as social progress. But how does that happen? What role does “culture” play?

I think society is increasingly valuing eg autistic thinking and (while there is much further to go), we have given some more rights and some more status to the spectrum of autistic thinking and other areas like this.

I think some rigorous work here would be insightful and useful. If the productivity or progress can be raised in these areas there could be strong benefits.

Running along side this, I’d be interested in rigorous work on Team and Individual productivity progress.

There could be an enormous win if robust findings could be confirmed here.

For example, Paul Graham (extremely successful in the start-up founder and investment space) has argued that maker time and manager time are very different schedules.

Essentially, maker time requires good lengths of the day devoted to the creative projects  (in my view, related to what we know about flow) whereas manager time needs shorter chunks of meeting time.

Where manager time interferes with maker time, you get a huge negative impact to maker productivity.


If this is correct and if we can guide for it, this could improve productivity and be of general benefit. Would this be progress? I think so, and of general public good. Why are there so many time management books? Tyler Cowen amongst others often asks about people’s “personal productivity function” ?  Can we actually discover anything robust here?

Let’s go one step further, we seem to have some tentative ideas about sleep and productive circadian rhythms of the day for certain people (eg night owls).

We have tentative ideas about intermittent fasting or diet and potential health benefits.

Is there any work on trying to combine these factors or ideas? 


If you current have poor productivity, but what you should do is change to a nightowl, maker schedule on an intermittent fasting schedule - could your productivity significantly increase?


And then how about combining this within teams? There is work on psychological safety*, and some thoughts as to  innovation seems to happen when teams understand each other’s work but are not too close or not too far away - but can we combine any of these possible insights?


From this can we create even more builder teams, like the Tesla’s, Stripes., etc of the world.


Perhaps it is too abstract and too difficult to do rigorously, but I think this would be a weirdly good area for UK ARPA to examine.

As extension, I’d look in to how we foster creativity. Specifically, I’d be interested in extending the work around “flow” and any rigorous study on the structure of “story” or “narratives”. And also an examination of forms of “educational mastery” 


Flow

Why flow? There is some suggestion that flow can significantly increase creative productivity (although there might be downsides in using flow to enter practice states that don’t lead to new development). Rigourous work around here that might be more widely applied could have strong benefits. Same for overall creativity.

Mihaly Csikszentmihalyi (Creativity: Flow and the Psychology of Discovery and Invention, 2013) has done work here but can it be extended and made wider known? If it can raise the creativeness of our top 20% (or anyone) could there be huge gains?

Drama and story

The basis of most (western) dramatic structure was written by Aristotle in his poetics around 330 BCE - so over 2300 years ago. While we have had some incremental changes and Shakespeare arguably stepped up this form there are a couple of way of thinking about this. One is that drama and story has been stagnating for a long time but another is that there is something fundamental about story structure that has persisted over centuries (maybe something Lindy? As Taleb might say)


Given the way that story/narrative/myth seems to really impact human behaviour (intersubjective myth for instance) and in world where humans might benefit being resistant to mis-information - I think there could be good gains from a rigourous study here.


Thinkers like Ray Dalio put strong weight on the hero quest story arcs in life and my weird suggestion is that a study around what we know about “story” as a social science exercise  would be insightful. 

This is probably too leftfield for them, but my next idea could be more mainstream and that is an examination of “educational mastery” especially in the context of online or Khan academy type innovations.

Educational Mastery

Patrick Collinson writes: “Educational psychologist Benjamin Bloom found that one-on-one tutoring using mastery learning led to a two sigma(!) improvement in student performance. The results were replicated. He asks in his paper that identified the "2 Sigma Problem": how do we achieve these results in conditions more practical (i.e., more scalable) than one-to-one tutoring?

In a related vein, this large-scale meta-analysis shows large (>0.5 Cohen's d) effects from direct instruction using mastery learning.

Is this a true effect and can we do more about it? Can it scale using online methods? 1-1 video ? Or if not, is there value to eg. randomly (or not) selecting some students and giving them mastery type learning. If just these small groups have two sigma improvements - could we see some significant gains?

I think ARPA could well study something in this area.  Nintil* did a thorough research round up suggesting the Bloom effect was not as large. But, 1-1 teaching did have a very robust effect. 

We could find a number of people willing to give 1-1 teaching as extra and maybe a number of students (across high performing or medium/low performing groups). If 1-1 can dramatically improve performance would this be worth studying or working on?

Building faster

Lastly, in this area it would be useful to examine why we seemed to be able to build infrastructure and certain other items faster 50 years ago. First, how true is this? UK managed to build Olympic sites in a moderately fast time frame but not eg. the tube extensions. This might not exactly be an ARPA area, but I think it could under pin a lot of innovation. (cf again Cowen, Collinson).

I think there’s an enormous amount that we do better, but can we learn from where we had speed before. Are there robust findings here? Or it just a nice to think venture capital thing.

My last huge area is on healthcare. 

Healthcare progress

I would also suggest there is work done on studying healthcare progress. Now there is a huge literature here, but I see less in a cross-disciplinary nature. This is intersectional with some other ideas here, but it would be what discoveries have most improved human health and how can we have more of them? What are the barriers or not.

Hand washing, weight control, diet, exercise and other low cost interventions are known but how best to synthesise this and can it be combined with newer technolofy and how intersectional with the social determinats of health?

This area will be a focus areas coming off the pandemic, but there is - to my reading - limited work on synthesing how best human health can be improved and the barriers to it.


And this is because of the incentives of where the private sector will focus its innovation and capture public good improvements or not. 


There are potentially very strong and perhaps moderately easy wins here. Two areas would be cost/benefits of areas of drug regulation. The UK has a particular opportunity here.


For instance, it could use EMEA and US  regulatory equivalence but go further and decide to approve certain medications quicker than those regulators. ( I think patient choice could be interesting here, post phase II and/or safety studies)

The UK could extend ideas it has started on “challenge trials” to see if this could significantly speed up areas of therapy development. There are areas probably more areas suitable for challenge trials and areas less suitable and not only COVID. ARIA could run a programme assessing and potentially funding some of this.  

Where would the cost/benefits of challenge trials help the UK/World in certain disease areas?


ARIA could go beyond narrow areas of regulation and even challenge trials but try an synthesis areas of public health.


Can robust work be done on how eg digital health data combined with preventative interventions could make huge, inexpensive, health interventions.   I think this could be a huge area. Many pilot trials have started (eg see a lot of the work Optum do) but some rigorous programmes here could be of enormous value.


In sum, we have ARIA. Let it explore some weird ideas. A few more transformational weird ideas would be a good thing and won’t displace all the other R&D things we are doing.


Links:

Dominic Cummings blog

On trees, World in Data but here on the conflicts in the data and conflicting data here.

Paul Graham, maker time

On Flow: Mihaly Csikszentmihalyi. Creativity: Flow and the Psychology of Discovery and Invention, 2013

Nintil on educational mastery

Patrick Collinson, fast things. And Cowen and Collinson on Progress Studies. 

Policy Exchange: https://policyexchange.org.uk/wp-content/uploads/Visions-of-Arpa.pdf

ON ARPA https://benjaminreinhardt.com/wddw


Why is the vaccine rollout slow and what we could do

A lack of imagination is holding us back

In New York 1947, 5 million people were vaccinated in 2 weeks

Like many, I have been puzzled by the seemingly slow vaccine rollout in the UK, US and many other countries. I do not automatically assume incompetence or bad actors. At first, I do not even automatically assume the vaccine roll out is slow. I thought I should investigate further. But slow it seems to be, although not everywhere.

Screenshot 2021-01-13 at 21.13.15.png

Israel is at 4-5x the pace of the UK and close to 10x the pace of the US. The United Arab Emirates is almost 3x the pace of the UK. Although the UK and US are doing better than Germany and France.

Screenshot 2021-01-13 at 21.14.31.png

How are we doing relative to history? We have built things fast in history (see Patrick Collinson list end). For instance:

On 24 June 1948, the Soviet Union initiated a blockade of Berlin. Two days later, the Berlin Airlift commenced. Over the following 463 days, the US, the UK, and France flew 277,000 flights with 300 aircraft to deliver the supplies required to support 2.2 million Berlin residents. On average, a supply aircraft landed every 2 minutes for 14 months.

I found a recent NYT article on how New York ran a vaccination programme in 1947 (link end). I went to the orginal review of the programme by Dr. Weinstein.

5 million people were vaccinated in 2 weeks and 6.35 million in less than a month.

The original article in the American Journal of Public Health (1947) is available here to review (link end)

Dr Weinsten writes:

Vaccination stations were set up in all police precincts, in addition to Health Department buildings and municipal hospitals and clinics. There was a total of 179 city installations being used for vaccination. Practically every hospital in the city setup a special clinic where vaccinations were given to all who applied, free of charge. The vaccine was furnished by the Health Department and was administered by doctors on the hospital staff. Many community organizations setup local centers staffed by volunteer physicians and clerks. 

Labour and industry cooperated by establishing vaccination stations in factories offices and union headquarters. In some cases their own positions did the vaccinating and others it was performed by health Department personnel. The station is maintained by the city remain open from 9 am until 10 pm including Saturdays and Sundays on April 26 those at the police print sinks were discontinued and on May 3 all other stations were closed. 

(The vaccination plan was drafted after 4 April).

The NYT article and a quick glance at other commentators have suggested these reasons for being slower today:

  • Regulation. This is at a city level vs centralised. But also the bureaucracy around registering volunteers.

  • Logistic delays. This is in getting vaccines to doctors. And quality control testing that is required (although that is partly regulation). 

  • Priortisation schedules. A complex process behind evaluating which batches go where. Essentially trying to get priority cohorts covered first.

  • Manufacturing Capacity. These are delays in glass vials, fill/finish capacity in specialised glass rather than pure vaccine supply.

  • A lack of trust in government. This supposedly means problems with vaccine hesitancy.

  • A lack of public health infrastructure.

Now while there seem to be elements of truth to those causal ideas many of them do not seem to hold up to the challenges in 1947. Health infrastructure today is more sophisticated and more plentiful both in absolute and per capita basis. The regulatory and logistical burden can part explain the gap and for instance the UK has much more vaccine than it has been able to administer but we certainly have capacity to do and I think we have both state and private capacity.

My theory is that we lack imagination. Or more precisely, the people in leadership positions either lack imagination or are too risk adverse in outlining a more ambitious plan.

Rather than saying why, we should be saying why not?

Rather than  a focus on errors of commission - taking a bad action - like lack of paper work for a volunteer - we ignore the errors of omission - simply taking good decisions.

What would that mean in practice? Applying 3 minutes of imagination time, I come up with the below. I am sure a group of school children allowed to use their imagaination could do better in a day.

  • Why not co-opt all police stations, fire stations and like?

  • Why not co-opt every pharmacy of size, and the expertise of the pharmacists, both public and private? Not only community pharmacies. (Sun newspaper claims offers from the private sector were shunned, although it’s not obvious if this has now been taken up - I’m unsure why they can not have been involved from the start)

  • Why not set up temporary open air type vaccination stations in our major parks in our cities?

  • Why not co-opt major business head quarters and industrial parks or gyms or leisure centres or restaurant chains.

  • Why not drive-ins?

  • Why not co-opt schools and all the places we use for polling?

  • Why not convince the logistics experts of Amazon and the like to take a sabbactical and help run our services (and give them so authority to have things done)

Countries probably don’t even have to be as extreme to have better roll outs. They could copy Israel (which also has an over 60 and key worker prioritisation list).

“In Israel our paramedics or nurses are able to travel with a set of 50 to a very distant point without wasting one single shot."

The country has 335 "drive-through" vaccination centres which operate extended hours.

At one, in the northern city of Haifa, doctor and recipient Natalie Roynik was in, jabbed and out in minutes without leaving the driving seat. (From Sky news)

And

Distributing the jabs quickly is crucial, and this is one area where the eagerness among Israelis to get vaccinated is accelerating the effort. Interest is so high that every day, queues of younger people hoping for leftover doses form in front of inoculation stations. WhatsApp groups filled with people contacting each other to secure these doses have also appeared.

And copy our past in terms of public information roll outs and co-opting private/public spaces to help. I know the UK is rolling outmass vaccination centres and using its health infrastructure, but we simply seem slow and it doesn’t necessarily seem a lack of resources. And while we can laud the Israeli use of digital health, New York City 1947 didn’t need digitisation.

There are legitimate debates around state capacity and if the right amount of investment has been made in the right areas.

However, my sense is this is not so much a state capacity problem in tangible infrastructure but a deficit within intangible capacity. In this case the imagination to dream more ambitiously and then the know how and social capital to make it happen.

The silver linings...Israel could be fully vaccinated in 3 months. 

The UK could take anywhere between 6 months to 12 months depending on how the roll out pace continues. 

I sincerely wish we could replicate some of the speed of the past.

https://www.thesun.co.uk/news/13661315/high-street-pharmacies-1m-covid-jabs-snubbed-vaccinate/

NYT article on 1947 vaccination.

The original article in the American Journal of Public Health (1947) is available here to review

Patrick Collison list of fast building.

COVID, why so many are mostly wrong, or only a little correct.

Summary: Vaccines are likely to give protection for at least c. 12 months and likely to reduce transmission rates, but vaccine hesitancy, mutation and maybe some amount of re-infection will mean that the virus stays with us permanently like influenza does. However like ‘flu we will find this disease manageable. We may also never know for sure why certain groups (eg men) suffer higher mortality. 

The medium to long term speculative thoughts is that this crisis will spur more innovation and creativity across several domains.

This is because many may conclude it is human innovation that has saved us and will save us. Similar thinking may be applied to climate challenges (I expect Bill Gates will double down on this in his next book). I also think - while with much pain- the creative arts will also react with more creativity, although extremely crimped near term, as people will have to find new ways of reaching audiences/consumers.


This is a long form read over why so many people are fairly wrong (or only a little correct) about COVID and why the information seems so confusing. I will attempt to touch on:

  • Predicting vaccines

  • Immunity and immune memory

  • Cross-protection

  • Different strains

  • Different genetics

  • Super-spreaders

  • Cultural differences

  • Data reporting differences

  • Complexity models

  • Re-infection

  • Narrow vs broad thinking (fox vs hedgehog)

  • Ideology

Back in August 2020, I made the point estimate judgement of an 80% chance of a vaccine by the end of 2020. Significantly above some observers estimates (although a good number of healthcare investors were making similar judgments).  I noted some of my thinking in my August blog.

What’s useful to note is why many expert observers were more pessimistic. I can summarise that those group were focused on past experiences, focused on the risks (which were clear) and anchored on previous examples. They were not willing to place faith in mRNA technology that had not produced commercial vaccine before even if much of the theory is well established.

Source: Google Finance

Source: Google Finance


Stock market prices embody future expectations that people with money (not reputation or press articles) buy and sell at. It’s very difficult typically to be ahead of this collective wisdom of the crowd. Still with in a stock price reveals a signal that can be interpreted.

If you look at Moderna’s (one of the vaccine makers) stock price - which embody many factors including politics, interests rates, etc - there was much of a run up from March to early November before the positive pivotal data in November. There are still future unknown events to come eg launch and distribution, but looking back one can suggest that investors with money were not super surprised by early November as much had already been “priced in” over March to October.


Mostly investors do not bet directly on a question such as “will there be a COVID vaccine in 2020?” But indirectly on stocks or other assets and prices which lead to money win/loss outcomes. These investors were suggesting through the Moderna stock price signal that there was a decent expectation of some success here.


I won’t rehash all the many science and socio-political points that went into my August forecast but suffice to say there are a number of people who do make and essentially bet behind these predictions.

Cross-immunity, herd-immunity, re-infection, strains, genetics and why everyone is only a little bit right.


Mostly - with rare exceptions - media articles will take a single look at a narrow domain question and present evidence in favour of a certain answer. Sometimes coloured by an ideology. (Even studies tend to look at a narrow question).


For example, if by ideas, you strongly favour individual choices you may balk at the idea of government imposed lockdowns and so you are drawn to articles suggesting Sweden or a “herd immunity” process as a way of proceeding without lockdowns. The actual data from Sweden does not matter too much - especially when you can find media articles to support your inclination.

Another example is re-infection. There are cases of re-infection, but it seems from what we know re-infection is rare but it can and does make article headlines.

[A distant simplistic parallel that people might understand is that you can get chickenpox twice (or rather, shingles after chickenpox) but it is rare.]


Still depending if you have an idea already about what we should be doing then a case of re-infection or an article about it can be used to support that view.

So you can put all of these statements together which have a little bit of truth to them.

  • There are asymptomatic carriers of COVID.

  • You can gain (some amount of) cross-protection for some (unknown) amount of time by exposure to other coronaviruses including the common cold. 

  • This level of protection will vary with strain, genetics, immune responses and memory - which in turn vary with factors such as age.

  • Different strains can act with different people’s genetics to cause varying levels of severity of disease.

  • Different people’s immune system will “remember” the virus differently (age, strain etc. variant)


All of this becomes confusing because we would like a simple answer of do I get cross-protection or not? Not the complex answer of it dependant strain, time and genetics (and perhaps environment)  and will not be static.

And from some of these simple parameters that can change we can have events such as “super-spreaders” where one person or one event (eg a sports or a night club evening) seem to cause many infections. The interplay of all those infection factors can produce those results. Or not.

In that sense - a distant parallel is with weather forecasting.  We can put together large trends to fairly accurate assess total infection cases in regions over  a few weeks or days, but predictions at the single person or event level are much more uncertain.

Other factors which interplay are cultural differences and reporting data differences. Certainly, if you have ever travelled through Japan then the cultural differences in hygiene and also in the populations general adherence to rules from authority (also see China, Taiwan) are very different from England or the US.

As an aside, I do think the politics of mask wearing especially in the early days of the pandemic in Europe and the US were surprising to me - although not in hindsight. There was (and is) a strand of thought as to how so simple an intervention could have an impact. A walk through a poorer country or even a more mixed one like South Africa would not scorn “simple” interventions so heavily (access to proper toilets and hygiene make huge impacts). I do think - again with hindsight - it is surprising that more weight was not given to first principles - in that we knew the virus was carried in aerosol droplets (and like colds, flus) and so the physical methods of transmission could well be interrupted by barriers like masks.

Putting this all together what does this mean? In my view, vaccines are likely to give protection for at least c. 12 months and likely to reduce transmission rates, but vaccine hesitancy, mutation and maybe some amount of re-infection will mean that the virus stays with us permanently like influenza does. However like ‘flu we will find this disease manageable. We may also never know for sure why certain groups (eg men) suffer higher mortality. 

The medium to long term speculative thoughts is that this crisis will spur more innovation and creativity across several domains.

This is because many will conclude it is human innovation that has saved us and will save us. Similar thinking may be applied to climate challenges (I expect Bill Gates will double down on this in his next book). I also think - while with much pain- the creative arts will also react with more creativity, although extremely crimped near term, as people will have to find new ways of reaching audiences/consumers.

Here are a mix of random thoughts and questions that I considered when thinking about COVID:

Where did SARS-CoV-2 come from?

Some uncertainty, but seems very likely that it came from animals (zoonotic, maybe bats) and crossed into humans. Evidence that is was present in China in November 2019 (as early as 17 Nov) and maybe earlier. Open question. We don’t know if the virus mutated in animals and then crossed to humans. Or crossed to humans and then mutated and crossed human-to—human.

Definitely seems NOT lab made (IMO).

https://www.nature.com/articles/s41591-020-0820-9

https://www.scmp.com/news/china/society/article/3074991/coronavirus-chinas-first-confirmed-covid-19-case-traced-back

Why have certain regions (Taiwan, South Korea, Singapore, Hong Kong) handled the pandemic better than others (Italy, Spain, all of Europe, US….)?

…Same for sectors and businesses ?

The high-performers had:

-Very prepared systems

-Responsive public health authorities

-Responsive general public

-Responsive private companies (at the request of the public health authorities)

But, they had very prepared systems + public because:

-They had dealt with the trauma and cost of SARS-classic

The actions were/included:

-Early responses (masks, restrictions)

-High testing (fast deployment + development of tests)

-Strict isolate, contact, trace protocols

-Travel bans and similar

-Tracking of quarantined people

There is a 124 point list of what Taiwan did:

https://www.vox.com/future-perfect/2020/3/10/21171722/taiwan-coronavirus-china-social-distancing-quarantine

https://jamanetwork.com/journals/jama/fullarticle/2762689

…Same for sectors and businesses ?

Some sectors/businesses:

-had more awareness on what exponential growth can look like (tech), and/or, 

-had more respect for the seriousness that China were taking (and put weight on that signal)

-more redundancy built into their supply chains (typically, as product considered critical, eg insulins, other must-have pharmaceuticals)

-more cash on balance sheets to deal with emergencies (typically these were maybe ear marked for litigation or other catastrophic events)

-ability to remote work

-business models that are resilient to COVID (eg. Video conference calls)

This has lead to:

(Parts of) Tech + Health + Utilities > most business

Big business > small business


Within countries / regions 

Some regions influenced by:

-understanding of exponential growth (Tech community in San Francisco)

-population density

-culture

-strains

-maybe weather?


Open Question: Why are death rates different across European regions, Asia etc ? Also, knows as heterogeneity.

We don’t know. 

We do know:

-Data is patchy

-Testing criteria are different

-Testing efficacy varies

-Older people, men, people with underlying diseases (eg heart problems) are more at risk

(But even here, there are regional differences with US rates of hospitalisation in the young much higher than in other regions).

-Different strains

-Different genetics

-Different cross protection

No one has a model that explains these intersecting factors.

One tentative suggestion is the difference in “viral load” or dosage of virus you get on first infection may explain part of this.

We do know viral load can have an impact with other viruses.

Open: Why are some people more susceptible than others?

This goes across many subgroups: Children, Men, but also differences in the young who do get impacted.

Open Question: Why are death rates so low in children? This pattern is consistent across regions even if rates vary. Explanations include:

  • Children’s immune system being more flexible and rapid

  • Adult immune system may over react due to priming with other coronaviruses

  • Adult immune system being slower

  • Other varieties of explanation…

See: Christakis https://twitter.com/NAChristakis/status/1243883141900763137

Open Question: Why are death rates higher in men? (also Co-morbidities)

We don’t know. Partial explanations that I have seen touted but with no evidence include:

-men being worse at hand washing/hygiene 

-men being more likely to smoke or use vapes.

But, essentially whatever your underlying risk the virus seems to magnify it (eg age, male, underlying diseases)…

Open Question: How long will immunity last? (Likely ranges, we have looking to be quite a few months, I’d would hone in on at least a year) 

Partly Open Question: How long does a person remain infectious? (We have some likely ranges)

Partly Open Question: How exactly is the virus spreading? (While we know it’s via viruses in droplets, we don’t really know if it’s surviving to infect people in open spaces as opposed to enclosed spaces. There’s tentative evidence that open spaces are safer (some outdoor mass events protests have not lead to super-spreading spikes but some internal ones have, also cf. different experiences in Italian cities, also Brazil) . Even if viruses can survive on cardboard in a lab how that works in the real world is unclear.)

Vaccine hesitancy, UK (79%) would take vaccine

Source: https://www.weforum.org/agenda/2020/11/fewer-people-say-they-would-take-a-covid-19-vaccine-now-than-3-months-ago

Source: https://www.weforum.org/agenda/2020/11/fewer-people-say-they-would-take-a-covid-19-vaccine-now-than-3-months-ago

Vaccine hesitancy, the ‘reluctance or refusal to vaccinate despite the availability of vaccines’, was listed among the World Health Organisation’s top ten threats to health in 2019.

In an August 2020 poll around one in four (26%) adults globally disagreed that they would take a vaccine for COVID-19 if it were available, with worry about side effects, followed by perception of effectiveness being mentioned most frequently as reasonsfor not getting a vaccine. This slipped further down in October. The November report from Ispos here. And WEF link here.